Bone Abstracts

CCN family member 2(CCN2)/Connective tissue growth factor (CTGF) is a multi-functional factor in proliferation, differentiation and migration of mesenchymal cells such as chondrocytes, osteoblasts and vascular endothelial cells. Recently, we also reported that CCN2/CTGF promotes osteoclastgenesis via induction of and interaction with DC-STAMP. We and other researchers reported that CCN2 binds to cytokines and receptors and modified their signaling. Therefore, we compr...